Advances in Oligoprotection

Liao, Hong and Mani, Dixit Sanjaya (2011) Advances in Oligoprotection. Neuroscience and Medicine, 02 (02). pp. 93-103. ISSN 2158-2912

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Abstract

Oligodendrocytes, the myelinating glial cells of the nervous system, in various disease states display great vulnerability to excitotoxic damage, oxidative stress, and inflammatory cytokines. Besides demyelinating diseases where oligoden-drocyte injury is primarily implicated, damage to them also occurs secondarily in various neuropathies. Oligoprotec-tion should, therefore, be looked into something not just as a means for protecting oligodendrocytes alone but also as a common target of protecting neurons and the neurogliovascular unit as a whole. In this review, we provide a descrip-tion on oligodendrocytes, the reasons for their vulnerability, the evolving new concepts of protecting neurovascular unit and recently neurogliovascular unit; the various diseases where oligodendrocyte injury is implicated with a brief idea on different injury mechanisms of oligodendrocytes. Finally, we present the summary of the drugs that have shown promising results in protecting oligodendrocytes or in protecting white matter as a whole in different in-vivo and in-vitro models.

Item Type: Article
Subjects: Souths Book > Medical Science
Divisions: Faculty of Engineering, Science and Mathematics > School of Geography
Depositing User: Unnamed user with email support@southsbook.com
Date Deposited: 31 Jan 2023 11:46
Last Modified: 15 Jun 2024 12:05
URI: http://research.europeanlibrarypress.com/id/eprint/99

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