Synthesis, Characterization and Antibacterial Evaluation of Some Substituted Pyrrolidines

Hussein, Mohammed (2016) Synthesis, Characterization and Antibacterial Evaluation of Some Substituted Pyrrolidines. Chemical Science International Journal, 17 (2). pp. 1-8. ISSN 2456706X

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Abstract

Series of substituted heterocyclic Chalcones 3-aryl-1-(thiophen-2-yl) prop-2-en-1-one 1-9 had been prepared by using Claisen-Schmidt condensation. In addition, series of substituted Schiff bases N-arylidene benzylamines 10-13 were prepared by the condensation of benzyl amine with various substituted aromatic aldehydes. The reaction of the above materials occurred through 1,3-anionic cycloaddition of azallyl anion of Schiff bases which acted as a nucleophile to the double bond of chalcones afforded the corresponding heterocycles (pyrrolidines 14-24). Spectral data and some physical properties were used to support the structures of the new products. The antibacterial activity of some prepared compounds were tested through its Inhibition effects on two kinds of bacteria.

Item Type: Article
Subjects: Souths Book > Chemical Science
Depositing User: Unnamed user with email support@southsbook.com
Date Deposited: 24 May 2023 10:03
Last Modified: 13 Sep 2024 08:02
URI: http://research.europeanlibrarypress.com/id/eprint/986

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