Katta, Jhansi and Rampilla, Venkatesh and Khasim, S. M. (2019) A Study on Phytochemical and Anticancer Activities of Epiphytic Orchid Aerides odorata Lindl. European Journal of Medicinal Plants, 28 (3). pp. 1-21. ISSN 2231-0894
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Abstract
Aim: The present study was carried out to evaluate the phytochemical composition and anticancer activities of leaf extract of Aerides odorata Lour., a widely distributed epiphytic herb found in the Eastern Ghats of Vizianagram district.
Methodology: The solvents like n-hexane, ethyl acetate and methanol were used to extract dried leaf material of A. odorata. These extracts were analysed for phytochemical constituents by GC-MS analysis and in vitro anticancer activity was done against two cancer cell lines (MCF-7 and HeLa cell line) by using MTT assay.
Results: Preliminary phytochemical analysis revealed the presence of alkaloids, coumarins, flavonoids, glycosides, phenols, and terpenoids. GC-MS analysis determines presence of 15 compounds in ethyl acetate and 14 compounds in methanol extracts respectively. Among two extracts a total 13 compounds have anticancer activity. Both the solvent extracts exhibit significant cancer cell growth inhibition with IC50 value ranging between 26.211 µg/mL to 59.061 µg/mL.
Conclusion: Methanol about the best solvent and its activity. Our result showed A. odorata is a promising source of anticancer drugs.
Item Type: | Article |
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Subjects: | Souths Book > Medical Science |
Depositing User: | Unnamed user with email support@southsbook.com |
Date Deposited: | 30 Mar 2023 09:30 |
Last Modified: | 23 May 2024 07:46 |
URI: | http://research.europeanlibrarypress.com/id/eprint/469 |