Severe dopaminergic neuron loss in rhesus monkey brain impairs morphine-induced conditioned place preference

Yan, Ting and Rizak, Joshua Dominic and Wang, Jianhong and Yang, Shangchuan and Ma, Yuanye and Hu, Xintian (2015) Severe dopaminergic neuron loss in rhesus monkey brain impairs morphine-induced conditioned place preference. Frontiers in Behavioral Neuroscience, 9. ISSN 1662-5153

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Abstract

It is well known that dopamine (DA) is critical for reward, but the precise role of DA in reward remains uncertain. The aim of this study was to determine what percentage of dopaminergic neurons in the primate brain is required for the expression of conditioned reward by measuring the performance of DA-deficient rhesus monkeys in a morphine-induced conditioned place preference (CPP) paradigm. Animals with mild Parkinsonian symptoms successfully developed and retained a morphine preference that was equivalent to control monkeys. However, these monkeys could not maintain the preference as well as controls when they retained severe Parkinsonian symptoms. On the other hand, monkeys initially in a severe Parkinsonian state developed a preference for morphine, but this preference was weaker than that of the controls. Histological results showed that the loss of dopaminergic neurons in monkeys that had severe Parkinsonian symptoms was about 80% in comparison to the control monkeys. All these data suggest that a severely impaired DA system alters rewarding-seeking behavior in non-human primates.

Item Type: Article
Subjects: Souths Book > Biological Science
Depositing User: Unnamed user with email support@southsbook.com
Date Deposited: 11 Mar 2023 10:28
Last Modified: 15 Jun 2024 12:05
URI: http://research.europeanlibrarypress.com/id/eprint/287

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