OXIDATIVE STATUS AND ORGAN DAMAGE MARKER PARAMETERS IN CALF CRYPTOSPORIDIOSIS

Aim: Neonatal calf diarrhoea is the major cause of calf deaths in the world. Although some pathogens are including
calf diarrhoea, Cryptosporidium spp. is the most determined microbial agent as protozoa. The main aim of this
research was to determine the blood oxidative status parameters of the calf with cryptosporidiosis. Also, heart, liver
and renal damage markers were also determined.
Materials and Methods: Totally healthy 15 calves and cryptosporidiosis-caused diarrheic 15 calves were used, in
this research. Serum oxidative status parameters (Malondialdehyde, total antioxidant status, superoxide dismutase,
catalase) were measured with ELISA. Liver (Aspartate aminotransferase, alkaline phosphatase, gamma
glutamyltransferase) and kidney (Creatinine, blood urea nitrogen) damage markers were measured by autoanalyzer,
whereas troponin I level, cardiac damage marker, was determined with chemiluminescence immunoassay
technique.
Results: Increased total antioxidant status was determined (P<0.05) in the diarrheic calves compared to control
group, while there was no any statistically significance changes determined in the oxidative status parameters. Also,
increased troponin I and blood urea nitrogen levels were measured (P<0.05) in the diarrheic calves.
Conclusion: It may be stated that major changes are not observed in the diarrheic calves with cryptosporidiosis,
but it may cause slightly cardiac and renal damage. However, histo-pathological exams should be done.